DSIP

DSIP 5mg Peptide

DSIP (delta sleep-inducing peptide) is a synthetic nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. The 5 mg presentation is a research material supplied for laboratory use. This page covers its basic identity, the research context in which it has been studied, and the documentation and handling points researchers should check before use.

What DSIP is

DSIP was first isolated and sequenced in the 1970s from rabbit brain dialysate. Schoenenberger and Monnier’s 1977 work reported that the purified material increased slow-wave electroencephalographic activity under the conditions of their experiments and established its nine-amino-acid sequence. Subsequent laboratory studies have examined the peptide in rodent and other models for effects on sleep architecture, stress responses, and certain neuroendocrine markers. These findings come from experimental systems; they do not establish that a commercially supplied preparation will produce the same results, nor do they support human or veterinary use. The material discussed here is intended solely for research.

Research context

Investigators have used DSIP to probe questions about sleep regulation and related physiological responses in controlled models. Reported observations include changes in slow-wave activity and interactions with stress or hormonal pathways, but results vary with species, dose range used in the experiment, route, and endpoints measured. Any protocol should include appropriate controls and should interpret outcomes within the limits of the assay rather than as evidence of a fully defined mechanism or clinical effect.

Documentation and quality

Identity and purity should be confirmed for the specific vial. A product name or catalog code identifies the compound type; only the lot number identifies the production run. A usable certificate of analysis lists the same lot number that appears on the vial and reports the analytical results for that batch—typically HPLC purity and mass-spectrometric confirmation of the expected mass. A missing or mismatched certificate cannot verify the material. HPLC and mass spectrometry characterise the sample; they do not demonstrate biological activity in any particular assay.

Handling notes

Store the unopened lyophilised material according to the supplier’s stability data, commonly at –20 °C and protected from light. Minimise freeze-thaw cycles. Reconstitution should follow the laboratory’s validated procedure and the supplier’s guidance; record the solvent, date, and final concentration so results remain traceable. A clear solution after reconstitution does not by itself confirm retained activity or analytical specifications. The 5 mg figure describes the amount supplied in the vial, not a recommended experimental concentration.

Summary

DSIP 5 mg is a synthetic nonapeptide research material with a documented history in experimental sleep studies. Selection for any experiment depends on matching the compound identity and lot-specific analytical data to the study requirements. Certificates of analysis tied to the vial lot remain the primary means of confirming what was supplied.